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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A303-192A-T | 10 µl (10 µg) | - |
2 - 8 business days* |
164.00€
|
|||
A303-192A | 100 µl (100 µg) | - |
2 - 8 business days* |
588.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: RNA-binding protein that plays a role in the regulation of alternative splicing... more
Product information "Anti-SLM-2"
Protein function: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:10564820, PubMed:19561594, PubMed:26758068). Involved in splice site selection of vascular endothelial growth factor (PubMed:15901763). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of neurexins NRXN1- 3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PubMed:26758068). Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity. May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing. Can bind FABP9 mRNA. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. [The UniProt Consortium]
Keywords: | Anti-SALP, Anti-SLM-2, Anti-KHDRBS3, Anti-RNA-binding protein T-Star, Anti-Sam68-like mammalian protein 2, Anti-Sam68-like phosphotyrosine protein, Anti-KH domain-containing, RNA-binding, signal transduction-associated protein 3 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A303-192A |
Properties
Application: | WB, IP |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: bovine, dog, guinea pig_10141, pig, panda, rhesus monkey, gorilla, chimpanzee, white-tufted-ear marmoset, crab-eating macaque, european domestic ferret, small-eared galago, northern white-cheeked gibbon) |
Immunogen: | synthetic peptide. The epitope recognized by A303-192A-T maps to a region between residue 175 and 225 of human Sam68-like Mammalian Protein 2 using the numbering given in entry NP_006549.1 (GeneID 10656). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K14942 | Matching products |
UniProt ID : | O75525 | Matching products |
Gene ID | GeneID 10656 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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