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This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Protein function: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus. [The UniProt Consortium]
Keywords:
Anti-SIP-1, Anti-TKA-1, Anti-NHERF2, Anti-NHERF-2, Anti-SLC9A3R2, Anti-SRY-interacting protein 1, Anti-Tyrosine kinase activator protein 1, Anti-NHE3 kinase A regulatory protein E3KARP, Anti-Sodium-hydrogen exchanger regulatory factor 2, SLC9A3R2 Polyclon
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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