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You can also order by e-mail: info@biomol.com
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are... more
Product information "Anti-SLC10A1"
The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids, the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. Protein function: As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins (PubMed:8132774, PubMed:14660639, PubMed:24867799, PubMed:34060352). It is strictly dependent on the extracellular presence of sodium (PubMed:8132774, PubMed:14660639, PubMed:24867799, PubMed:34060352). It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate (PubMed:14660639, PubMed:34060352). Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (PubMed:33222321). [The UniProt Consortium]
Keywords: | NTCP, GIG29, SLC10A1, Na(+)/bile acid cotransporter, Solute carrier family 10 member 1, Na(+)/taurocholate transport protein, Hepatic sodium/bile acid cotransporter, Cell growth-inhibiting gene 29 protein, Sodium/taurocholate cotransporting polypeptide, S |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-90464 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | mouse, rat |
Immunogen: | A synthetic peptide of human SLC10A1 |
Database Information
KEGG ID : | K14341 | Matching products |
UniProt ID : | Q14973 | Matching products |
Gene ID | GeneID 6554 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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