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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-R31062 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Zinc finger E-box-binding homeobox 2, also... more
Product information "Anti-SIP1 (ZEB2)"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Zinc finger E-box-binding homeobox 2, also known as Smad Interacting Protein 1 (SIP1) or Zinc finger homeobox 1B (ZFHX1B), is a protein that in humans is encoded by the ZEB2 gene. The gene is a member of the ZEB1/Drosophila Zfh1 family of 2-handed zinc finger/homeodomain proteins and functions as a DNA-binding transcriptional repressor that interacts with activatedSMADs, the transducers ofTGF-betasignaling, and interacts with the nucleosome remodeling and histone deacetylation(NURD) complex. By radiation hybrid analysis, Nagase et al.(1998) mapped the gene to chromosome 2. Wakamatsu et al.(2001) mapped the gene to chromosome 2q22. Vandewalle et al.(2005) showed that expression of mouse Sip1 in human epithelial cells caused a morphologic change from an epithelial to a mesenchymal phenotype. Expression ofSNAI1in epithelial cells triggers an epithelial-mesenchyme transition. Beltran et al.(2008) showed that synthesis of SIP1 was upregulated following SNAI1 expression in human cell lines. Protein function: Transcriptional inhibitor that binds to DNA sequence 5'- CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212). [The UniProt Consortium]
Keywords: | Anti-SMADIP1, Anti-HRIHFB2411, Anti-Smad-interacting protein 1, Anti-Zinc finger homeobox protein 1b, Anti-Zinc finger E-box-binding homeobox 2, SIP1 Antibody (ZEB2) |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | R31062 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | An amino acid sequence from the C-terminus of human Smad Interacting Protein 1 (DMQQRRKYQRKQGFQ) |
Format: | Purified |
Database Information
KEGG ID : | K23560 | Matching products |
UniProt ID : | O60315 | Matching products |
Gene ID | GeneID 9839 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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