Anti-Sin3A

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A300-725A-T	10 µl (2 µg)		-		2 - 8 business days*		164.00€
A300-725A	100 µl		-		2 - 8 business days*		588.00€

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Protein function: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1... more

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Product information "Anti-Sin3A"

Protein function: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression. [The UniProt Consortium]

Keywords:	Anti-Transcriptional corepressor Sin3a, Anti-Paired amphipathic helix protein Sin3a, Anti-Histone deacetylase complex subunit Sin3a
Supplier:	Bethyl Laboratories
Supplier-Nr:	A300-725A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: mouse)
Immunogen:	synthetic peptide. The epitope recognized by A300-725A-T maps to a region between residue 375 and 425 of human SIN3 homolog A using the numbering given in entry NP_056292.1 (GeneID 25942).
Format:	Antigen Affinity Purified