Anti-SHTN1

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ATA-HPA037943.25 25 µl -

7 - 10 business days*

335.00€
ATA-HPA037943.100 100 µl -

7 - 10 business days*

446.00€
 
Protein function: Involved in the generation of internal asymmetric signals required for neuronal... more
Product information "Anti-SHTN1"
Protein function: Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1- dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 100% and to rat: 98%
Keywords: Anti-Shootin1, Anti-KIAA1598, Anti-Shootin-1
Supplier: Atlas Antibodies
Supplier-Nr: HPA037943

Properties

Application: ICC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, rat
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: MNSSDEEKQL QLITSLKEQA IGEYEDLRAE NQKTKEKCDK IRQERDEAVK KLEEFQKISH MVIEEVNFMQ NHLEIEKTCR ESAEALATKL NKEN (ATA-APrEST80405)

Database Information

UniProt ID : A0MZ66 | Matching products
Gene ID GeneID 57698 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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