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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ARG57067.50 | 50 µl | - | - |
6 - 14 business days* |
488.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Co-chaperone that binds misfolded and hydrophobic patches-containing client... more
Product information "Anti-SGTA, clone 19E8"
Protein function: Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Probably functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457). [The UniProt Consortium]
Keywords: | Anti-SGT, Anti-UBP, Anti-SGTA, Anti-Alpha-SGT, Anti-Vpu-binding protein, Anti-Small glutamine-rich tetratricopeptide repeat-containing protein alpha |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG57067 |
Properties
Application: | WB, FC |
Antibody Type: | Monoclonal |
Clone: | 19E8 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant fragment around aa. 1-313 of Human SGTA |
Format: | Purified |
Database Information
KEGG ID : | K16365 | Matching products |
UniProt ID : | O43765 | Matching products |
Gene ID | GeneID 6449 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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