Anti-SGO2

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A301-261A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A301-261A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated... more

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Product information "Anti-SGO2"

Protein function: Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation. Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. [The UniProt Consortium]

Keywords:	Anti-SGOL2, Anti-Tripin, Anti-Shugoshin 2, Anti-Shugoshin-2, Anti-Shugoshin-like 2
Supplier:	Bethyl Laboratories
Supplier-Nr:	A301-261A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: rhesus monkey, gorilla, chimpanzee, crab-eating macaque, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by A301-261A-T maps to a region between residue 175 and 225 of human shugoshin-like 2 using the numbering given in entry NP_689737.3 (GeneID 151246).
Format:	Antigen Affinity Purified