Anti-Semaphorin 6A (Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1) (SEMA6A, KIAA1368, SEMAQ)

The transmembrane semaphorin Semaphorin 6A is expressed in developing neural tissue and is required for proper development of the thalamocortical neuron projection. Semaphorin 6A belongs to a subfamily characterized by an extracellular semaphorin domain, a transmembrane domain, and a long cytoplasmic tail. Members of this class can repel sympathetic and dorsal root ganglion axons in vitro, consistent with a traditional role as guidance signals. It was also suggested that Semaphorin 6A has a role in retrograde signaling. Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.