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This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This gene is expressed in a variety of tissues, and the protein is localized to the perinuclear structures. Protein function: May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation. [The UniProt Consortium]
Keywords:
Anti-SelM, Anti-Selenoprotein M, SELM Polyclonal Antibody
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