Anti-SARS-CoV-2 Beta Variant Spike Protein, clone 25D10.E3.F9

SARS-CoV-2 Beta Variant Spike Protein Antibody is directed against SARS Coronavirus 2 Spike (S2) Beta B.1.351 Variant Protein. The product was purified from roller bottle culture by protein A chromatography.  BLAST analysis was used to suggest reactivity with related Coronavirus proteins.  No reactivity was seen against B.1.429/CAL.20, B.1.526, B.1.1.7, B.1.617.2, P.1, or B.1.525. Cross reactivity with homologues from other sources has not been determined. Protein function: [Spike protein S1]: Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. The major receptor is host ACE2 (PubMed:32142651, PubMed:33607086, PubMed:32155444). When S2/S2' has been cleaved, binding to the receptor triggers direct fusion at the cell membrane (PubMed:34561887). When S2/S2' has not been cleaved, binding to the receptor results in internalization of the virus by endocytosis leading to fusion of the virion membrane with the host endosomal membrane (PubMed:32221306, PubMed:32075877). Alternatively, may use NRP1/NRP2 (PubMed:33082294, PubMed:33082293) and integrin as entry receptors (PubMed:35150743). The use of NRP1/NRP2 receptors may explain the tropism of the virus in human olfactory epithelial cells, which express these molecules at high levels but ACE2 at low levels (PubMed:33082293). The stalk domain of S contains three hinges, giving the head unexpected orientational freedom (PubMed:32817270). [The UniProt Consortium]