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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ARG44284.50 | 50 µl | - | - |
6 - 14 business days* |
592.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: NAD(+) hydrolase, which plays a key role in axonal degeneration following... more
Product information "Anti-SARM1"
Protein function: NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:25908823, PubMed:27671644, PubMed:28334607). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:15123841, PubMed:16964262, PubMed:20306472, PubMed:25908823). Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide, NAD(+) cleavage promoting cytoskeletal degradation and axon destruction (PubMed:25908823, PubMed:28334607, PubMed:30333228, PubMed:31128467, PubMed:31439793, PubMed:32049506, PubMed:32828421, PubMed:31439792, PubMed:33053563). Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed:29395922). Can activate neuronal cell death in response to stress (PubMed:20306472). Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38 (PubMed:16964262). [The UniProt Consortium]
Keywords: | Anti-HsTIR, Anti-HsTIR, Anti-hSARM1, Anti-hSARM1, Anti-MyD88-5, Anti-MyD88-5, Anti-NADase SARM1, Anti-NADase SARM1, Anti-Tir-1 homolog, Anti-Tir-1 homolog, Anti-NAD(+) hydrolase SARM1, Anti-NAD(+) hydrolase SARM1, Anti-NADP(+) hydrolase SARM1, Anti-NADP(+ |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG44284 |
Properties
Application: | ICC, IF, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Full length recombinant human SARM1 protein |
MW: | 79 kD |
Format: | Antigen Affinity Purified |
Database Information
UniProt ID : | Q6SZW1 | Matching products |
Gene ID | GeneID 23098 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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