Anti-S100A13, clone S100A13/7482

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. The S-100 protein family consists of a group of calcium-binding proteins, that exhibit cell and tissue-specific expression. The expression levels of its members differ in various pathological conditions. The extracellular functions of the S-100 family may include the ability to enhance neurite outgrowth, involvement in inflammation and motility of tumor cells. S-100A13 is a 98 amino acid protein with 2 EF-hand calcium-binding domains. High levels of S-100A13 mRNA are present in skeletal muscle, heart, kidney, ovary, small intestine and pancreas. S-100A13 translocates in response to elevated intracellular calcium levels induced by Angiotensin II. S-100A13 co-localizes with S-100A1 on human chromosome 1q21.3, the site where the majority of S-100 proteins cluster. Protein function: Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine. [The UniProt Consortium]