Anti-RPE65 (Retinal Pigment Epithelium-Specific Protein Membrane Receptor p63, 65kD)

Anti-RPE65 (Retinal Pigment Epithelium-Specific Protein Membrane Receptor p63, 65kD)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
R1659-70A.100 100 µl - -

1 - 19 business days

546.00€
 
RPE65 is a major protein of the retinal pigment epithelium (RPE). RPE65 is essential for the... more
Product information "Anti-RPE65 (Retinal Pigment Epithelium-Specific Protein Membrane Receptor p63, 65kD)"
RPE65 is a major protein of the retinal pigment epithelium (RPE). RPE65 is essential for the regeneration of rhodopsin in the visual cycle. Mutations in RPE65 are responsible for certain forms of autosomal recessive severe retinal dystrophy, including Leber Congenital Amaurosis (LCA). Loss of function results in a block in retinoid processing required for the synthesis of 11-cis retinal and the accumulation of retinyl esters in the RPE. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunofluorescence/Immunocytochemistry and Flow Cytometry. Other applications not tested. Recommended Dilutions: Western Blot: 1:500-1:1000, recognizes a band at ~65kD representing bovine RPE65 protein. Also been tested on recombinant human protein in COS7 cells. , Immunohistochemistry (Frozen): 1:250 on murine retinal sections, Immunohistochemistry (Paraffin): 1:250-1:500, Immunofluorescence (IC): 1:10-1:500 on ARPE19 cells, Flow Cytometry: 1:250, Optimal dilution determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier: United States Biological
Supplier-Nr: R1659-70A

Properties

Application: ELISA, FC, ICC, IF, IHC, WB
Antibody Type: Monoclonal
Clone: 8B99
Conjugate: No
Host: Mouse
Reactivity: Bovine, Dog, Human, Mouse, Swine, Rat
Immunogen: Bovine RPE microsomal membrane proteins.
Format: Affinity Purified

Database Information

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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