Anti-ROBO1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A301-265A-T	10 µl (2 µg)		-		2 - 8 business days*		164.00€
A301-265A	100 µl		-		2 - 8 business days*		588.00€

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Protein function: Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular... more

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Product information "Anti-ROBO1"

Protein function: Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. Plays a role in the regulation of cell migration via its interaction with MYO9B, inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP- bound RHOA (PubMed:26529257). May be required for lung development. [The UniProt Consortium]

Keywords:	Anti-DUTT1, Anti-ROBO1, Anti-H-Robo-1, Anti-Roundabout homolog 1, Anti-Deleted in U twenty twenty
Supplier:	Bethyl Laboratories
Supplier-Nr:	A301-265A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: dog, rabbit, orangutan, gorilla, chimpanzee, white-tufted-ear marmoset, european domestic ferret, african elephant, naked mole rat, little brown bat)
Immunogen:	synthetic peptide. The epitope recognized by A301-265A-T maps to a region between residue 1275 and 1325 of human roundabout, axon guidance receptor, homolog 1 using the numbering given in entry NP_002932.1 (GeneID 6091).
Format:	Antigen Affinity Purified