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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ATA-HPA016812.25 | 25 µl | - |
7 - 10 business days* |
335.00€
|
|||
ATA-HPA016812.100 | 100 µl | - |
7 - 10 business days* |
446.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target... more
Product information "Anti-RNF41"
Protein function: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 100% and to rat: 100%
Keywords: | Anti-FLRF, Anti-RNF41, Anti-SBBI03, EC=2.3.2.27, Anti-RING finger protein 41, Anti-E3 ubiquitin-protein ligase NRDP1, Anti-RING-type E3 ubiquitin transferase NRDP1 |
Supplier: | Atlas Antibodies |
Supplier-Nr: | HPA016812 |
Properties
Application: | WB, IHC, ICC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: DAVLQAVIKR SLVESGCPAS IVNELIENAH ERSWPQGLAT LETRQMNRRY YENYVAKRIP GKQAVVVMAC ENQHMGDDMV QEPGLVMIFA HGVEEI (ATA-APrEST73761) |
Database Information
KEGG ID : | K11981 | Matching products |
UniProt ID : | Q9H4P4 | Matching products |
Gene ID | GeneID 10193 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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