Anti-RNF40

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG41178.100	100 µl		-	-	6 - 14 business days*		624.00€

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Protein function: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates... more

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Product information "Anti-RNF40"

Protein function: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B, reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. [The UniProt Consortium]

Keywords:	Anti-RBP95, Anti-BRE1B, Anti-RNF40, Anti-BRE1-B, Anti-RING finger protein 40, Anti-E3 ubiquitin-protein ligase BRE1B, Anti-RING-type E3 ubiquitin transferase BRE1B, Anti-95 kDa retinoblastoma-associated protein
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG41178

Properties

Application:	ChIP, ICC, IF, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant fusion protein corresponding to aa. 1-300 of Human RNF40 (NP_055586.1)
MW:	113 kD
Format:	Affinity Purified