Anti-RNase H2B (C-Term) Rabbit Monoclonal Antibody (Clone RM433)

RNase H2B is a non-catalytic accessory subunit of RNase H2, the major nuclear enzyme responsible for degrading RNA/DNA hybrids and hydrolyzing ribonucleotides misincorporated during genomic replication. It is localized to nuclear replication foci, where it forms a complex with RNase H2A and RNase H2C, and contains a C-terminal PIP-box motif that meditates its interaction with proliferating cell nuclear antigen (PCNA), which confirms strand specificity to RNase H2. Biallelic mutations in RNASEH2B induce Aicardi-Goutières syndrome (AGS), an autoimmune disorder characterized by constitutive activation of cGAS and IFN overproduction. Mutations in RNASEH2B are also associated with uncomplicated hereditary spastic paraplegia. Cayman's RNase H2B (C-Term) Rabbit Monoclonal Antibody (Clone RM433) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: Aicardi-Goutieres Syndrome 2 Protein, Deleted in Lymphocytic Leukemia 8, DLEU8, Ribonuclease H2 Subunit B. Immunogen: Peptide from the C-terminal region of human RNase H2B. Clone Designation: RM433. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) RNase H2B.