Anti-Retinol Binding Protein 4 / RBP4, clone RBP4/4046

Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V4111-20UG 20 µg - -

3 - 10 business days*

332.00€
NSJ-V4111-100UG 100 µg - -

3 - 10 business days*

752.00€
 
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Retinol (Vitamin A) is... more
Product information "Anti-Retinol Binding Protein 4 / RBP4, clone RBP4/4046"
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Retinol (Vitamin A) is transported in the blood bound to its carrier protein, retinol-binding protein (RBP), also designated plasma retinol-binding protein (PRBP) or RBP4. A member of the lipocalin family, RBP conveys retinol from stores in the liver to peripheral tissues. In plasma, RBP binds transthyretin (TTR, formerly called prealbumin) to prevent glomerular filtration of low molecular weight RBP in the kidneys. The stability of this complex holds diagnostic importance because the molar ratio of RBP:TTR provides an indirect way to indicate marginal Vitamin A deficiency. Vitamin A deficiency blocks the secretion of RBP, resulting in defective delivery and supply to epidermal cells. Originally identified solely as a transporter protein, recent studies correlating increased levels of RBP expression in adipose tissue with Insulin resistance have generated research into the possible roles the protein may play in the pathogenesis of type 2 diabetes and obesity. Protein function: Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496). [The UniProt Consortium]
Keywords: Anti-RBP4, Anti-PRO2222, Retinol Binding Protein 4 Antibody / RBP4
Supplier: NSJ Bioreagents
Supplier-Nr: V4111

Properties

Application: IHC (paraffin)
Antibody Type: Monoclonal
Clone: RBP4/4046
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: A recombinant partial protein (within amino acids 29-148) from the human protein
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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