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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES13430.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES13430.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The protein encoded by this gene is a helicase that is important for genome stability. The... more
Product information "Anti-RECQ5"
The protein encoded by this gene is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011], Protein function: DNA helicase that plays an important role in DNA replication, transcription and repair (PubMed:20643585, PubMed:22973052). Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability (PubMed:20231364). Associates also with POLR1A and enforces the stability of ribosomal DNA arrays (PubMed:27502483). Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress (PubMed:22013166). Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis (PubMed:28575661). Required for efficient DNA repair, including repair of inter-strand cross-links (PubMed:23715498). Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000,IHC-p 1:50-300, ELISA 2000-20000. Cellular localization: [Isoform Beta]: Nucleus, nucleoplasm . Nucleus . Recruited to sites of DNA damage, such as single-strand breaks and inter-strand cross-links, and at stalled replication forks. Re-localizes from the nucleolus into the nucleus after replicative stress and significantly associates with WRN during S-phase (PubMed:23180761). ., [Isoform Alpha]: Cytoplasm ., [Isoform Gamma]: Cytoplasm .
Keywords: | Anti-RECQ5, Anti-RecQ5, Anti-RECQL5, EC=3.6.4.12, Anti-RecQ protein-like 5, Anti-ATP-dependent DNA helicase Q5, Anti-DNA helicase, RecQ-like type 5, RECQ5 rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES13430 |
Properties
Application: | WB, ELISA, IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, rat, mouse, |
Immunogen: | Synthesized peptide derived from human RECQ5 AA range: 647-697 |
Format: | Purified |
Database Information
KEGG ID : | K10902 | Matching products |
UniProt ID : | O94762 | Matching products |
Gene ID | GeneID 9400 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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