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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ATA-HPA062144.25 | 25 µl | - |
7 - 10 business days* |
335.00€
|
|||
ATA-HPA062144.100 | 100 µl | - |
7 - 10 business days* |
446.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Post-transcriptional repressor of mRNAs containing a conserved stem loop motif,... more
Product information "Anti-RC3H2"
Protein function: Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation. miRNA- binding protein that regulates microRNA homeostasis. Enhances DICER- mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). Involved in the ubiquitination of MAP3K5 (PubMed:24448648, PubMed:26489670). Able to interact with double-stranded RNA (dsRNA) (PubMed:26489670). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 88% and to rat: 89%
Keywords: | Anti-MNAB, Anti-RC3H2, Anti-Roquin-2, Anti-RING finger protein 164, Anti-RING-type E3 ubiquitin transferase Roquin-2, Anti-Membrane-associated nucleic acid-binding protein, Anti-RING finger and CCCH-type zinc finger domain-containing protein 2 |
Supplier: | Atlas Antibodies |
Supplier-Nr: | HPA062144 |
Properties
Application: | ICC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: QKEPPKQKKQ SLGEDHVILE EQKTILPVTS CFSQPLPVSI SNASCLPITT SVSAGNLILK THVMSEDKND FLKPVANGKM V (ATA-APrEST94224) |
Database Information
KEGG ID : | K15690 | Matching products |
UniProt ID : | Q9HBD1 | Matching products |
Gene ID | GeneID 54542 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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