Anti-RBM25/RED120

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A301-067A-T	10 µl (2 µg)		-		2 - 8 business days*		164.00€
A301-067A	100 µl		-		2 - 8 business days*		588.00€

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Protein function: RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing.... more

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Product information "Anti-RBM25/RED120"

Protein function: RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. [The UniProt Consortium]

Keywords:	Anti-RBM25, Anti-RNPC7, Anti-RED120, Anti-Protein S164, Anti-RNA-binding protein 25, Anti-RNA-binding motif protein 25, Anti-Arg/Glu/Asp-rich protein of 120 kDa, Anti-RNA-binding region-containing protein 7
Supplier:	Bethyl Laboratories
Supplier-Nr:	A301-067A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: mouse)
Immunogen:	synthetic peptide. The epitope recognized by A301-067A-T maps to a region between residue 150 and 200 of human RNA binding motif protein 25 (Arg/Glu/Asp-rich protein, 120 kDa) using the numbering given in entry AAF19255.1 (GeneID 58517).
Format:	Antigen Affinity Purified