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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES11214.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES11214.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
function:May play a role in regulating axonal regeneration and plasticity in the adult central... more
Product information "Anti-R4RL2"
function:May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.,PTM:Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells, where BRE is released as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein.,similarity:Belongs to the Nogo receptor family.,similarity:Contains 8 LRR (leucine-rich) repeats.,subcellular location:Localized to the surface of neurons, including axons.,tissue specificity:Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid., Protein function: Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG. Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis, protection against apoptosis is probably mediated by MAG. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200). [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000. Cellular localization: Cell membrane , Lipid-anchor, GPI-anchor . Membrane raft . Cell projection, dendrite . Perikaryon . Cell projection, axon . Localized to the surface of neurons, including axons. Detected close to synapses, but is excluded from synapses. .
Keywords: | Anti-NgR2, Anti-Nogo receptor-like 3, Anti-Nogo-66 receptor homolog 1, Anti-Reticulon-4 receptor-like 2, Anti-Nogo-66 receptor-related protein 2, R4RL2 rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES11214 |
Properties
Application: | WB, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, rat, mouse |
Immunogen: | Synthesized peptide derived from human protein . at AA range: 290-370 |
MW: | 46 kD |
Format: | Purified |
Database Information
KEGG ID : | K16661 | Matching products |
UniProt ID : | Q86UN3 | Matching products |
Gene ID | GeneID 349667 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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