Anti-R4RL1

function:May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.,similarity:Belongs to the Nogo receptor family.,similarity:Contains 8 LRR (leucine-rich) repeats.,subcellular location:Localized to the surface of neurons, including axons.,tissue specificity:Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen., Protein function: Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis, protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200). [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000. Cellular localization: Cell membrane , Lipid-anchor, GPI-anchor . Membrane raft . Perikaryon . Cell projection . Localized to the surface of neurons, including axons. .