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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-20-1064-50 | 50 µl | - |
3 - 11 business days* |
373.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This antibody recognizes FAP-1, including FAP-1 isoforms, FAP-1 (also known as Fas-associated... more
Product information "Anti-PTPN13/PTPL1 (FAP1)"
This antibody recognizes FAP-1, including FAP-1 isoforms, FAP-1 (also known as Fas-associated phosphatase-1, PTPN13, PTP-BAS, hPTPIE, and PTPL1) is a member of the protein tyrosine phosphatase (PTP) family FAP-1 phosphatase is thought to be important in the Fas signaling pathway. FAP-1 binds to the cytosolic tail of the Fas receptor (Apo1, CD95) and inhibits Fas-induced apoptosis. Increased FAP-1 protein levels in some tumor cell lines and tumor tissues correlates with resistance to Fas-mediated apoptosis. In general, FAP-1 expression has been found to be highest in cell lines and tissues that are relatively resistant to Fas-mediated apoptosis. Gene transfer-mediated elevations in FAP-1 partially abolished Fas-induced apoptosis in a T cell line which is consistent with an inhibitory effect of FAP-1 on Fas signal transductions. Additionally, FAP-1 expression correlates with Fas resistant in ovarian cancer cell lines and FAP-1 is commonly expression in ovarian cancers. Protein function: Tyrosine phosphatase which regulates negatively FAS- induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). [The UniProt Consortium]
Keywords: | Anti-PNP1, Anti-FAP-1, Anti-hPTPE1, Anti-PTP-E1, Anti-PTPN13, Anti-PTP-BAS, Anti-Protein-tyrosine phosphatase 1E, Anti-Protein-tyrosine phosphatase PTPL1, Anti-Fas-associated protein-tyrosine phosphatase 1, Polyclonal antibody to PTPN13/PTPL1 (FAP1) |
Supplier: | Abeomics |
Supplier-Nr: | 20-1064 |
Properties
Application: | IP, IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | A synthetic peptide of human FAP-1 (amino acids 1760-1775 EPTRQENWTPLKNDLE) was used as immunogen for this antibody |
Format: | Sera |
Database Information
KEGG ID : | K02374 | Matching products |
UniProt ID : | Q12923 | Matching products |
Gene ID | GeneID 5783 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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