Anti-PTK7

Anti-PTK7 Antibody was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity with PTK7 with Human, Rat and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity with PTK7 from other sources has not been determined. PTK7 antibody detects PTK7 protein. Protein-tyrosine kinases (PTKs) play important roles in regulating cell proliferation and differentiation during development. One member of the PTK family, PTK7, has been suggested to regulate the planar cell polarity (PCP) pathway in vertebrates and may play a role in neural convergent extension and neural tube closure. PTK7 has also been implicated in the development of cancer. Loss of PTK7 expression was seen in several melanoma cell lines and biopsies. Conversely, high-throughput analysis of acute myeloid leukemia samples showed an increased level of PTK7 expression compared to normal bone marrow and purified CD34+ cells. Multiple isoforms of PTK7 are known to exist. Anti-PTK7 antibodies are ideal for investigators invovled in cancer and cell cycle protein research.