Anti-PTEN (C-Term) Rabbit Monoclonal Antibody (Clone RM265)

Phosphatase and tensin homolog (PTEN) is a tumor suppressor with roles in cell division, cell migration, and apoptosis. It is ubiquitously expressed and localized to the cytosol and nucleus where it dephosphorylates phosphatidylinositol-(3,4,5)-triphosphate (PIP3) to phosphatidylinositol-(3,4)-diphosphate (PIP2) to antagonize PI3K signaling and regulates spliceosome assembly and pre-mRNA splicing, respectively. PTEN inhibits cell cycle progression and induces apoptosis, as well as inhibits cell adhesion and migration in vitro. PTEN deletions have been found in various cancers, including glioblastomas and prostate, breast, and kidney cells. Germline mutations in PTEN induce a variety of syndromes, including Cowden, Bannayan-Riley-Ruvalcaba, Proteus, and Proteus-like syndromes, which are characterized by increased risk of cancers, developmental delays, autism spectrum disorders, and macroencephaly. Cayman's PTEN (C-Term) Rabbit Monoclonal Antibody (Clone RM265) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: MMAC1, Mutated in Multiple Advanced Cancers 1, Phosphatidylinositol-(3,4,5)-triphosphate 3-phosphatase and Dual-specificity Protein Phosphatase, TEP1. Immunogen: Peptide from the C-terminal region of human PTEN. Clone Designation: RM265. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) PTEN.