Anti-PSME3

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA012510.25	25 µl		-		7 - 10 business days*		300.00€
ATA-HPA012510.100	100 µl		-		7 - 10 business days*		421.00€

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Protein function: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a... more

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Product information "Anti-PSME3"

Protein function: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 100% and to rat: 100%

Keywords:	Anti-PA28g, Anti-PSME3, Anti-REG-gamma, Anti-PA28gamma, Anti-Ki nuclear autoantigen, Anti-11S regulator complex subunit gamma, Anti-Proteasome activator 28 subunit gamma, Anti-Proteasome activator complex subunit 3
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA012510

Properties

Application:	WB, IHC, ICC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: QEVKLKVDSF RERITSEAED LVANFFPKKL LELDSFLKEP ILNIHDLTQI HSDMNLPVPD PILLTNSHDG LDGPTYKKRR LDECEEAFQG TKVFVMPNGM LKSNQQLVDI IEKVKPEIRL LIEKCNT (ATA-APrEST70826)