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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core... more
Product information "Anti-PSMB9"
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Protein function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. [The UniProt Consortium]
Keywords: | Anti-LMP2, Anti-PSMB9, EC=3.4.25.1, Anti-Macropain chain 7, Anti-Proteasome chain 7, Anti-Proteasome subunit beta-1i, Anti-Low molecular mass protein 2, Anti-Proteasome subunit beta type-9, Anti-Really interesting new gene 12 protein, PSMB9 Polyclonal Ant |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-60439 |
Properties
Application: | WB, IF |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | Recombinant protein of human PSMB9 |
Database Information
KEGG ID : | K02741 | Matching products |
UniProt ID : | P28065 | Matching products |
Gene ID | GeneID 5698 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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