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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay32273-100 | 100 µl | - |
6 - 10 business days* |
480.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Prostate-specific antigen (PSA) is an androgen-regulated serine protease and member of the tissue... more
Product information "Anti-PSA Rabbit Monoclonal Antibody (Clone RM323)"
Prostate-specific antigen (PSA) is an androgen-regulated serine protease and member of the tissue kallikrein family that is encoded by KLK3 in humans. It is synthesized with a leader sequence, which is cleaved to generate the enzymatically inactive precursor protein proPSA, which is then cleaved between arginine and isoleucine at positions 7 and 8, respectively, to generate enzymatically active PSA. PSA is expressed primarily by the secretory epithelial cells in the acini and ducts of the prostate gland and is the major protein in seminal fluid where it cleaves enogelin I and II, proteins that mediate gel formation in semen. It is expressed at lower levels in the paraurethral and perianal glands, breast, thyroid, and placental tissues, and apocrine sweat glands. In prostate cancer, the prostate epithelial basement membrane is disrupted which allows PSA to enter the peripheral circulation where it is bound by the protease inhibitor alpha-1-antichymotrypsin (ACT). Serum levels of PSA are commonly used for preventative prostate cancer screening. Cayman's PSA Rabbit Monoclonal Antibody (Clone RM323) can be used for ELISA, immunohistochemistry (IHC), and Western blot (WB, non-reducing conditions) applications. The antibody recognizes free PSA and PSA complexed with ACT (PSA-ACT) from human samples.Synonyms: Kallikrein-3, Kallikrein-related Peptidase 3, Prostate-specific Antigen. Immunogen: Native human PSA purified from seminal fluid. Clone Designation: RM323. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: ELISA, IHC, WB (non-reducing conditions). Cross Reactivity: (+) PSA, (+) PSA-ACT complex.
Keywords: | Kallikrein-3, Kallikrein-related Peptidase 3, Prostate-specific Antigen |
Supplier: | Cayman Chemical |
Supplier-Nr: | 32273 |
Properties
Application: | ELISA, IHC, WB (non-reducing) |
Antibody Type: | Monoclonal |
Clone: | RM323 |
Conjugate: | No |
Host: | Rabbit |
Immunogen: | Native human PSA purified from seminal fluid |
Format: | Purified |
Database Information
KEGG ID : | K01351 | Matching products |
UniProt ID : | P07288 | Matching products |
Gene ID | GeneID 354 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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