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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES10044.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES10044.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this... more
Product information "Anti-PRP8"
Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq, Jul 2008], Protein function: Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome (PubMed:10411133, PubMed:11971955, PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:29361316, PubMed:30315277, PubMed:29360106, PubMed:29301961, PubMed:30728453, PubMed:30705154). Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. [The UniProt Consortium] Recommended dilutions: IHC-p 1:50-300. Cellular localization: Nucleus . Nucleus speckle .
Keywords: | Anti-p220, Anti-PRPC8, Anti-PRPF8, Anti-PRP8 homolog, Anti-Splicing factor Prp8, Anti-220 kDa U5 snRNP-specific protein, Anti-Pre-mRNA-processing-splicing factor 8, PRP8 rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES10044 |
Properties
Application: | IHC, IF |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | Synthesized peptide derived from human protein . at AA range: 160-240 |
MW: | 256 kD |
Format: | Purified |
Database Information
KEGG ID : | K12856 | Matching products |
UniProt ID : | Q6P2Q9 | Matching products |
Gene ID | GeneID 10594 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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