Anti-PROX1, clone CL13474

Prospero homeobox protein 1 - Protein function: Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. [The UniProt Consortium] Enhanced validation: N/A. Concentration: 1 mg/ml. Immunogen homology (mouse/rat): ENSMUSG00000010175: 100%, ENSRNOG00000003694: 99%. Buffer formulation: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.