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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-36-3061-20 | 20 µg | - |
3 - 11 business days* |
375.00€
|
|||
ABE-36-3061-100 | 100 µg | - |
3 - 11 business days* |
853.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
PTPN6, which is also designated as SHP-1, is expressed primarily in hematopoietic cells and... more
Product information "Anti-Protein Tyrosine Phosphatase, non-receptor type 6 Monoclonal Antibody (Clone: CPTC-PTPN6-2)"
PTPN6, which is also designated as SHP-1, is expressed primarily in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. It maps to 12p13, a region commonly involved in leukemia-associated chromosomal abnormalities. SHP-1 plays a role in modulating intracellular signaling for various molecules. In T-cell lymphomas and other malignancies, SHP-1 phosphatase expression is lost, by a thus far undetermined mechanism. Preliminary studies sµggest that it may be helpful in differentiating mantle/marginal zone lymphomas (SHP-1+) from follicular lymphomas (SHP-1 negative). Protein function: Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. [The UniProt Consortium]
Keywords: | Anti-HCP, Anti-PTPN6, Anti-PTP-1C, Anti-SH-PTP1, EC=3.1.3.48, Anti-Protein-tyrosine phosphatase 1C, Anti-Protein-tyrosine phosphatase SHP-1, Anti-Hematopoietic cell protein-tyrosine phosphatase, Anti-Tyrosine-protein phosphatase non-receptor type 6, Anti- |
Supplier: | Abeomics |
Supplier-Nr: | 36-3061 |
Properties
Application: | ELISA, WB |
Antibody Type: | Monoclonal |
Clone: | CPTC-PTPN6-2 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant human full-length PTPN6 protein |
Database Information
KEGG ID : | K05697 | Matching products |
UniProt ID : | P29350 | Matching products |
Gene ID | GeneID 5777 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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