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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
P8950-02C.50 | 50 µl | - | - |
3 - 19 business days* |
610.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Prions are large cell membrane-anchored glycoproteins that are normally localized to the... more
Product information "Anti-Prion Protein (PrP, CD230), clone 6D685"
Prions are large cell membrane-anchored glycoproteins that are normally localized to the presynaptic membrane of neurons in mammalian brain. Prions are likely to be involved in synaptic transmission. In prion diseases, such as Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler-Scheinker syndrome (GSS), Fatal Familial Insomnia (FFI), Alpers Syndrome, and Kuru, the normal cellular form of this protein (PrPc) is transformed into an altered, proteolysis-resistant form upon coming into contact with an infectious prion protein (PrPsc) from another host. This altered prion protein accumulates in cytoplasmic vesicles of diseased individuals, forming lesions, vacuoles, and amyloid deposits. This antiserum can routinely be used without further purification. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilutions: ELISA: 1:5000-1:20,000, Western Blot: 1:5000-1:20,000. PrP from brain homogenates of BSE-infected cattle appears with three glycosylation- dependent bands between 16 and 36kD. Treatment of the homogenates with proteinase K under defined conditions degrades the abundant PrP-c molecules, revealing the shortened PrP-Sc. Proteinase K cleaves some residues from PrP-Sc, causing an apparent decrease in its MW. Recombinant bovine PrP-c runs at 27kD, the dimer at 48kD. , Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier: | United States Biological |
Supplier-Nr: | P8950-02C |
Properties
Application: | ELISA, WB |
Antibody Type: | Monoclonal |
Clone: | 6D685 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | bovine, hamster, human, mouse, sheep |
Immunogen: | Sequence 108-113 of bovine prion protein (PrP). Human PrP aa 97-102. |
Database Information
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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