Anti-PPP1R15A

PPP1R15A (Protein Phosphatase 1 Regulatory Subunit 15A) is a Protein Coding gene. Diseases associated with PPP1R15A include Malignant Pleural Mesothelioma. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein kinase binding.This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. Protein function: Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. [The UniProt Consortium]