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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES14002.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES14002.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Magnesium-independent polyisoprenoid diphosphatase that catalyzes the... more
Product information "Anti-PPAC2"
Protein function: Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates (PubMed:16464866, PubMed:19220020, PubMed:20110354). Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation (PubMed:16464866, PubMed:23568778). May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway (PubMed:20110354). May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins (PubMed:20110354). Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols (PubMed:18930839). May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine- 1-phosphate (PubMed:18930839, PubMed:20110354). [The UniProt Consortium] Recommended dilutions: WB 1:500-2000. Cellular localization: Endoplasmic reticulum membrane , Multi-pass membrane protein . Nucleus envelope . Nucleus inner membrane .
Keywords: | Anti-PA-PSP, Anti-LPRP-B, Anti-Phospholipid phosphatase 6, Anti-PPAP2 domain-containing protein 2, Anti-Lipid phosphatase-related protein-B, Anti-Presqualene diphosphate phosphatase, Anti-Type 1 polyisoprenoid diphosphate phosphatase, PPAC2 rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES14002 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Synthesized peptide derived from human PPAC2 AA range: 145-195 |
Format: | Purified |
Database Information
KEGG ID : | K22904 | Matching products |
UniProt ID : | Q8IY26 | Matching products |
Gene ID | GeneID 403313 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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