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Discount Promotion
Promotion:
Get 15% Discount on Antibodies and Biosimilars by Abeomics!
*1
*1 Offer expires 30/06/2024
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Discount | Price |
---|---|---|---|---|---|---|---|---|
ABE-11-12016-100 | 100 µg | - |
3 - 11 business days* |
15 %
|
387.00€
328.95€ |
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
POU3F2 is a developmental neural cell-specific POU domain transcription factor and is crucial for... more
Product information "Anti-POU3F2"
POU3F2 is a developmental neural cell-specific POU domain transcription factor and is crucial for cell lineage determination. In melanoma lesions, cells expressing high levels of POU3F2 show enhanced invasive and metastatic capacity that can in part be explained by repression of MITF (Micropthalmia-associated Transcription Factor) expression via POU3F2 binding to its promoter. POU3F2 is expressed exclusively in the central nervous system, more specifically in post-mitotic neurons and glia. Protein function: Transcription factor that plays a key role in neuronal differentiation. Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes. [The UniProt Consortium]
Keywords: | Anti-BRN2, Anti-Brn-2, Anti-OTF-7, Anti-Oct-7, Anti-POU3F2, Anti-Brain-2, Anti-Octamer-binding protein 7, Anti-Octamer-binding transcription factor 7, Anti-POU domain, class 3, transcription factor 2, Anti-Brain-specific homeobox/POU domain protein 2, Pol |
Supplier: | Abeomics |
Supplier-Nr: | 11-12016 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: mouse) |
Immunogen: | A partial length recombinant POU3F2 protein (amino acids 220-421) was used as the immunogen for this antibody. |
Format: | Purified |
Database Information
KEGG ID : | K09365 | Matching products |
UniProt ID : | P20265 | Matching products |
Gene ID | GeneID 5454 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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