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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ATA-HPA006721.25 | 25 µl | - |
7 - 10 business days* |
300.00€
|
|||
ATA-HPA006721.100 | 100 µl | - |
7 - 10 business days* |
421.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: DNA polymerase specifically involved in the DNA repair by translesion synthesis... more
Product information "Anti-POLH"
Protein function: DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:24449906, PubMed:24553286, PubMed:16357261). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'- deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'- dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 63% and to rat: 61%
Keywords: | Anti-POLH, Anti-RAD30, Anti-RAD30 homolog A, Anti-DNA polymerase eta, Anti-Xeroderma pigmentosum variant type protein |
Supplier: | Atlas Antibodies |
Supplier-Nr: | HPA006721 |
Properties
Application: | IHC, ICC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: PPLTMLFLCA TKFSASAPSS STDITSFLSS DPSSLPKVPV TSSEAKTQGS GPAVTATKKA TTSLESFFQK AAERQKVKEA SLSSLTAPTQ APMSNSPSKP SLPFQTSQST GTE (ATA-APrEST71086) |
Database Information
KEGG ID : | K03509 | Matching products |
UniProt ID : | Q9Y253 | Matching products |
Gene ID | GeneID 5429 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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