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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-44-1071-500 | 500 µl | - |
3 - 11 business days* |
1,217.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Postmeiotic Segregation Increased 2 (PMS2) is a DNA repair protein involved in mismatch repair.... more
Product information "Anti-PMS2 Monoclonal Antibody (Clone:IHC412)"
Postmeiotic Segregation Increased 2 (PMS2) is a DNA repair protein involved in mismatch repair. Mutations and deficiencies in the PMS2 gene have been linked to microsatellite instability, and malignancies such as hereditary nonpolyposis colorectal cancer and endometrial cancer. Anti-PMS2 is recommended to be used as part of a panel along with antibodies against MLH1, MSH2, and MSH6. Protein function: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2- MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. [The UniProt Consortium]
Keywords: | EC=3.1.-.-, Anti-PMS1 protein homolog 2, Anti-DNA mismatch repair protein PMS2, Anti-Mismatch repair endonuclease PMS2, Anti-PMS2 Monoclonal Antibody (Clone:IHC412) |
Supplier: | Abeomics |
Supplier-Nr: | 44-1071 |
Properties
Application: | ELISA, IHC |
Antibody Type: | Monoclonal |
Clone: | IHC412 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant Human PMS2 |
Format: | Purified |
Database Information
KEGG ID : | K10858 | Matching products |
UniProt ID : | P54278 | Matching products |
Gene ID | GeneID 5395 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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