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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-36-3051-20 | 20 µg | - |
3 - 11 business days* |
375.00€
|
|||
ABE-36-3051-100 | 100 µg | - |
3 - 11 business days* |
853.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
PMEPA1 (prostate transmembrane protein, androgen induced 1 is a 287 amino acid single-pass... more
Product information "Anti-PMEPA1 / TMEPAI (Tumor Suppressor Oncoprotein) Monoclonal Antibody (Clone: PMEPA1/2696)"
PMEPA1 (prostate transmembrane protein, androgen induced 1 is a 287 amino acid single-pass membrane protein that contains WW-binding motifs and localizes to the cell membrane. Expressed at high levels in prostate, kidney and ovary, PMEPA1 interacts with NEDD4 and may play a role in regulating AR (androgen receptor) levels, specifically in prostate cells. Down regulation of PMEPA1 is observed in prostate tumors, sµggesting that PMEPA1 may exhibit activity as a tumor suppressor. Overexpression of this protein may play a role in multiple types of cancer. Protein function: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome- mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). [The UniProt Consortium]
Keywords: | Anti-STAG1, Anti-PMEPA1, Anti-Protein TMEPAI, Anti-Solid tumor-associated 1 protein, Anti-Transmembrane prostate androgen-induced protein, Anti-Prostate transmembrane protein androgen induced 1, Anti-PMEPA1 / TMEPAI (Tumor Suppressor Oncoprotein) Monoclon |
Supplier: | Abeomics |
Supplier-Nr: | 36-3051 |
Properties
Application: | IHC |
Antibody Type: | Monoclonal |
Clone: | PMEPA1/2696 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant full-length human PMEPA1 protein |
Database Information
UniProt ID : | Q969W9 | Matching products |
Gene ID | GeneID 56937 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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