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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES6514.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES6514.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This gene is the human homolog of murine plunc, and like the mouse gene, is specifically... more
Product information "Anti-PLUNC"
This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known. [provided by RefSeq, Aug 2014], Protein function: Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) (PubMed:25223608). Plays a role in the innate immune responses of the upper airways (PubMed:23499554, PubMed:23132494). Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae (PubMed:23499554, PubMed:23132494, PubMed:27145151). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus (PubMed:24124190, PubMed:24043776). Plays a role in the airway inflammatory response after exposure to irritants (PubMed:11425234). May attract macrophages and neutrophils (PubMed:23132494). [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ,Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.. Cellular localization: Secreted . Apical side of airway epithelial cells. Detected in airway surface liquid, nasal mucus and sputum.
Keywords: | Anti-LUNX, Anti-BPIFA1, Anti-SPLUNC1, Anti-Short PLUNC1, Anti-Von Ebner protein Hl, Anti-Lung-specific protein X, Anti-Tracheal epithelium-enriched protein, Anti-BPI fold-containing family A member 1, Anti-Nasopharyngeal carcinoma-related protein, PLUNC r |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES6514 |
Properties
Application: | IHC, IF, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, rat, mouse, |
Immunogen: | Synthesized peptide derived from the Internal region of human PLUNC. |
Format: | Purified |
Database Information
KEGG ID : | K25375 | Matching products |
UniProt ID : | Q9NP55 | Matching products |
Gene ID | GeneID 51297 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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