Protein function: Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which have been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. [The UniProt Consortium]
Anti-PIP1, Anti-hPIP1, Anti-PAK1IP1, Anti-PAK1-interacting protein 1, Anti-PAK/PLC-interacting protein 1, Anti-WD repeat-containing protein 84, Anti-p21-activated protein kinase-interacting protein 1
Human (Expected: Orangutan, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Northern White-cheeked Gibbon)
synthetic peptide. The epitope recognized by A301-549A-T maps to a region between residue 290 and 340 of human PAK/PLC-interacting protein 1 (WD repeat protein 84) using the numbering given in entry NP_060376.2 (GeneID 55003).