Anti-PION, CT (PION, GSAP, Gamma-secretase-activating protein, Protein pigeon homolog, Gamma-secreta

Anti-PION, CT (PION, GSAP, Gamma-secretase-activating protein, Protein pigeon homolog, Gamma-secreta
Item number Size Datasheet Manual SDS Delivery time Quantity Price
040075.200 200 µl - -

1 - 19 business days

557.00€
 
Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD, MIM... more
Product information "Anti-PION, CT (PION, GSAP, Gamma-secretase-activating protein, Protein pigeon homolog, Gamma-secreta"
Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD, MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1, MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP, MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]). Applications: Suitable for use in Western Blot, Immunohistochemistry, ELISA, Recommended Dilution: ELISA: 1:1,000, Western Blot: 1:100-500, Immunohistochemistry: 1:10-50, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-GSAP, Anti-PION
Supplier: United States Biological
Supplier-Nr: 040075

Properties

Application: ELISA, IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: PION antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 536-565 amino acids from the C-terminal region of human PION.
Format: Affinity Purified

Database Information

UniProt ID : A4D1B5 | Find alternatives
Gene ID GeneID 54103 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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