Anti-PINK1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG57613.100	100 µl		-	-	6 - 14 business days*		624.00€

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Protein function: Protects against mitochondrial dysfunction during cellular stress by... more

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Product information "Anti-PINK1"

Protein function: Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN (PubMed:14607334, PubMed:15087508, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:25527291). Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (PubMed:23620051). Activates PRKN in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10. [The UniProt Consortium]

Keywords:	Anti-BRPK, Anti-PINK1, Anti-PTEN-induced putative kinase protein 1, Anti-Serine/threonine-protein kinase PINK1, mitochondrial
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG57613

Properties

Application:	ICC, IF, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	Recombinant protein of Human PINK1
MW:	30 kD
Format:	Affinity Purified