Anti-PINK1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
600-401-DN9	100 µg		-	-	6 - 10 business days*		684.00€

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Anti-PINK1 antibody was affinity purified from monospecific antiserum by immunoaffinity... more

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Product information "Anti-PINK1"

Anti-PINK1 antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. PINK1 antibody is human, mouse and rat reactive. At least two isoforms are known to exist, this antibody will only detect the longer isoform. PINK1 antibody will detect the cleaved and uncleaved form of PINK1. Protein function: Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582). [The UniProt Consortium]

Keywords:	Anti-BRPK, Anti-PINK1, Anti-PTEN-induced putative kinase protein 1, Anti-Serine/threonine-protein kinase PINK1, mitochondrial
Supplier:	Rockland Immunochemicals
Supplier-Nr:	600-401-DN9

Properties

Application:	ELISA, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	16 amino acid peptide near the N-terminus of human PINK1.
Format:	Purified