Anti-PIK3R4

Phosphoinositide 3-kinase regulatory subunit 4, also known asPI3-kinase regulatory subunit 4orPI3-kinase p150 subunitorphosphoinositide 3-kinase adaptor protein, orVPS15is an enzyme that in humans is encoded by thePIK3R4gene. The PI3-kinases regulate cellular signaling networks that are involved in processes linked to the survival, growth, proliferation, metabolism and specialized differentiated functions of cells. The subversion of this network is common in cancer and has also been linked to disorders of inflammation. Protein function: Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate, different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). [The UniProt Consortium]