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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ATA-HPA068792.25 | 25 µl | - |
7 - 10 business days* |
300.00€
|
|||
ATA-HPA068792.100 | 100 µl | - |
7 - 10 business days* |
421.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase,... more
Product information "Anti-PIAS2"
Protein function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 95% and to rat: 44%
Keywords: | Anti-DIP, Anti-Miz1, Anti-PIASX, Anti-PIAS2, Anti-ARIP3, EC=2.3.2.-, Anti-PIAS-NY protein, Anti-DAB2-interacting protein, Anti-E3 SUMO-protein ligase PIAS2, Anti-E3 SUMO-protein transferase PIAS2, Anti-Msx-interacting zinc finger protein |
Supplier: | Atlas Antibodies |
Supplier-Nr: | HPA068792 |
Properties
Application: | ICC, IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: TSVTTTSSHE SSTHVSSSSS RSETGVITSS GSNIPDIISL D (ATA-APrEST88896) |
Database Information
KEGG ID : | K16063 | Matching products |
UniProt ID : | O75928 | Matching products |
Gene ID | GeneID 9063 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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