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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES10000.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES10000.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger... more
Product information "Anti-PI3R6"
Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014], Protein function: Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis, signaling seems to involve RRAS. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000. Cellular localization: Cytoplasm . Cell membrane , Peripheral membrane protein . Translocated to the plasma membrane in a Ras-dependent manner. .
Keywords: | Anti-PIK3R6, Anti-p87PIKAP, Anti-C17orf38, Anti-p84 PIKAP, Anti-p84 PI3K adapter protein, Anti-p87 PI3K adapter protein, Anti-Phosphoinositide 3-kinase regulatory subunit 6, Anti-Phosphoinositide 3-kinase gamma adapter protein of 87 kDa, PI3R6 rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES10000 |
Properties
Application: | WB, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, rat, mouse, |
Immunogen: | Synthesized peptide derived from human protein . at AA range: 280-360 |
MW: | 82 kD |
Format: | Purified |
Database Information
KEGG ID : | K21290 | Matching products |
UniProt ID : | Q5UE93 | Matching products |
Gene ID | GeneID 146850 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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