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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay29290-100 | 100 µl | - |
6 - 10 business days* |
601.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Phospholipase C beta2 (PLCbeta2) is an enzyme that catalyzes the hydrolysis of... more
Product information "Anti-Phospholipase C beta2"
Phospholipase C beta2 (PLCbeta2) is an enzyme that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the secondary messengers inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). It is approximately 135 kDa and is composed of a pleckstrin homology domain, four EF-hand motifs, a catalytic domain, and a C2 domain that are common to all PLCs, as well as a 400-amino acid C-terminal region that is required for PLCbeta2 activation by the G-protein subunits Galphaq or Galpha11. PLCbeta2 is also activated by Gbetagamma subunits. Upon activation by a G-protein subunit, PLCbeta2 initiates intracellular signal transduction of extracellular signals using calcium as a cofactor. PLCbeta2 colocalizes with T1R and T2R taste receptors and Plcb2-/- mice exhibit selective and complete loss of sweet, amino acid, and bitter tastes. Plcb2-/- mice also exhibit increased coxsackievirus A16-induced pro-inflammatory cytokine production and decreased survival compared with wild-type mice. Cayman's Phospholipase C beta2 Polyclonal Antibody can be used for immunohistochemistry (IHC) and immunofluorescence (IF) applications.Synonyms: 1-Phosphatidylinositol 4,5-bisphosphate Phosphodiesterase beta2, PLCbeta2, Phosphoinositide Phospholipase C beta2. Immunogen: Peptide from the C-terminal region of human PLCbeta2. MW: ~135 kDa. Formulation: (Request formulation change), 100 µl of affinity-purified polyclonal antibody from pooled serum. Storage Buffer: 10 mM HEPES, pH 7.5, with 150 mM sodium chloride, 100 µg/ml BSA, and 50% glycerol. Host: Rabbit. Applications: IHC, IF.
Keywords: | 1-Phosphatidylinositol 4,5-bisphosphate Phosphodiesterase beta2, Phosphoinositide Phospholipase C beta2, PLCbeta2 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 29290 |
Properties
Application: | IHC, IF |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, primates |
Immunogen: | Peptide from the C-terminal region of human PLC?2 |
MW: | 135 kD |
Format: | Affinity Purified |
Database Information
KEGG ID : | K05858 | Matching products |
UniProt ID : | Q00722 | Matching products |
Gene ID | GeneID 5330 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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