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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES19939.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES19939.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Lysine demethylase that demethylates both histones and non- histone proteins... more
Product information "Anti-PHF2"
Protein function: Lysine demethylase that demethylates both histones and non- histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters. [The UniProt Consortium] Recommended dilutions: WB 1:1000-2000. Cellular localization: Nucleus, nucleolus . Chromosome, centromere, kinetochore .
Keywords: | Anti-GRC5, Anti-PHD finger protein 2, Anti-Lysine-specific demethylase PHF2, PHF2 rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES19939 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | Synthesized peptide derived from human PHF2 AA range: 74-124 |
Format: | Purified |
Database Information
KEGG ID : | K19414 | Matching products |
UniProt ID : | O75151 | Matching products |
Gene ID | GeneID 5253 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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